Serum lactate dehydrogenase activity as a biomarker in children with sickle cell disease

Serum lactate dehydrogenase (LDH) levels were studied in children with HbSS and HbSC in a single institution, and their relationship to cerebral vasculopathy as assessed by transcranial Doppler scanning (TCD). All children with HbSS (n = 97) and HbSC (n = 18) who underwent a TCD scan in 2006 were studied. Lactate dehydrogenaseLDH levels were higher in HbSS patients than HbSC (581 IU/l vs. 305 IU/l, P < 0.001). In children with HbSS, LDH correlated significantly with haemoglobin , reticulocytes, aspartate transaminase and creatinine. lactate dehydrogenase LDH also correlated positively and significantly with TCD measurements in the middle and anterior cerebral artery circulations in the children with HbSS.

PMID: 18028483 [PubMed - as supplied by publisher]
Br J Haematol. 2007 Nov 19
Department of Paediatric Haematology, King’s College School of Medicine, King’s College Hospital, Denmark Hill, London, UK.