Lactate dehydrogenase

Human lactate dehydrogenase isoenzymes are primarily used by cells in specific tissue. Human LDH Isoenzymes, also known as lactic dehydrogenase, are responsible for converting muscle lactic acid into pyruvic acid, an essential step in producing cellular energy.

When injury occurs, cells containing specific LDH isoenzymes are released in the bloodstream. Analyzing specific LDH isoenzyme ratios helps identify certain patterns in order to aid in the diagnosis of disease such as heart attack, lung injury, lung disease, liver or muscle disease, advanced cancers and autoimmune diseases.

Human lactate dehydrogenase LD(LDH) isoenzyme elevation associations:

Human LD1 isoenzyme : germ cell tumors
Human LD1> LD2 isoenzyme : renal or myocardial infarction, megaloblastic anemia, hemolysis
Human LD3 isoenzyme : platelet destruction, reactive, lymphadenopathy, lymphoma, lymphocytosis, pulmonary infarction, pneumonia, advanced cancer, acute pancreatitis
Human LD4 isoenyzme various solid tumors
Human LD5 isoenzyme : primary liver disease, liver anoxia, muscle injury or dystrophy; All forms: renal disease, carcinomatosis, collagen vascular vascular disease, overwhelming sepsis, DIC

Used in General Chemistry Controls by IVD Clinical diagnostic Manufactures such as Lee Biosolutions also offers animal source lactate dehydrogenase. Lactate Dehydrogenase is available as Rabbit LDH Lactate dehydrogenase, chicken LDH lactate dehydrogenase, porcine LDH lactate dehydrogenase and bovine LDH lactate dehydrogenase.